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Filtered Search Results
Medchemexpress LLC Acridine orange 10-nonyl bromide | 75168-11-5 | 99.5% | 472.50 | 25 MG
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Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin with an excitation wavelength (λex) of 489 nm and an emission wavelength (λem) of 525 nm. It is used for research purposes only.
- Fluorescent probe for cardiolipin.
- Can be used to quantify cardiolipin in isolated mitochondria.
- At 4.75 μM, it saturates mitochondrial binding sites in 1.5 X 10^6 cells within 15 minutes at 20°C.
- Upon interaction with cardiolipin, the dye's excitation and emission wavelengths shift from 496 nm and 525 nm to 450 nm and 640 nm, respectively.
- Increasing amounts of cardiolipin (0 to 30 μM) and other acidic phospholipids in thin-walled vesicles, when added to 45 μM Acridine Orange 10-Nonyl Bromide, changes the red fluorescence emission measured at 640 nm according to the liposome composition.
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Medchemexpress LLC Cinchonidine (α-Quinidine) | 485-71-2 | 99.6% | 294.39 | 25 G
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Cinchonidine is a cinchona alkaloid found in plants such as *Cinchona officinalis*. It serves as a building block in asymmetric synthesis and exhibits antimalarial activities.
- Acts as a weak inhibitor of the serotonin transporter (SERT)
- Used as a building block in asymmetric synthesis
- Exhibits antimalarial activities
- Available in solid, white to off-white appearance
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Sigma Aldrich Fine Chemicals Biosciences PTAA a polytriaryl amine s1G
PTAA poly(triaryl amine) semiconductor is an organic p-type semiconductor with hole mobilities of 10A3nbspup to 10A2nbspcm2nbspVA1nbspsA1 which results in a high carrier mobility. It is a stable glassy polymer and has good ionization potential for thick film diodes.
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Medchemexpress LLC Sapitinib | 848942-61-0 | 200 MG
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Sapitinib (AZD-8931) is a reversible, ATP competitive EGFR inhibitor with IC50s of 4, 3, and 4 nM for EGFR, ErbB2, and ErbB3 in cells, respectively. It demonstrates potent inhibitory effects on erbB2 in ligand-independent MCF-7 cl24 cells, significantly inhibits Akt phosphorylation, and induces apoptosis in human IBC cells.
- Reversible, ATP competitive EGFR inhibitor
- Potent inhibitory effect on erbB2 in ligand-independent MCF-7 cl24 cells
- Significantly inhibits phosphorylation of Akt in SUM149 and FC-IBC-02 cells
- Inhibits proliferation and induces apoptosis in human IBC cells
- Active in xenograft tumor models responsive to EGFR inhibition alone or EGFR or erbB2 inhibition
- Causes pharmacodynamic changes in proliferation and apoptosis markers in human tumor xenograft models
- Favorable oral pharmacokinetics in rat and dog
- Low human hepatocyte turnover
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Accela Chembio Inc 2 | 8-quinolinediol | 100g | 15450-76-7 | MFCD00216696 | 97+% | Shelf Life: 1260 Days | Light Sensitive
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2 | 8-quinolinediol | 100g | 15450-76-7 | MFCD00216696 | 97+% | Shelf Life: 1260 Days | Light Sensitive
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Apexbio Technology LLC BMS-626529 701213-36-7 200mg
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BMS-626529 is a small molecule inhibitor designed to block HIV-1 attachment to host cells Its mechanism involves binding to the viral envelope protein gp120 thereby hindering gp120-mediated interactions with CD4 receptors on CD4 T cells and preventing initial viral entry In cell-based assays BMS-626529 shows strain-specific antiviral activity with IC50 values mostly below 10 nM and notably low picomolar IC50 against highly susceptible HIV-1 isolates This molecule serves as a research tool to investigate HIV-1 entry inhibition and virus-host interaction mechanisms in biomedical studies
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Medchemexpress LLC hsa-miR-31-5p mimic 5nmol | 5nmol
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hsa-miR-31-5p mimics are small chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000431159 CYANINE5.5 AMINE 5MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000429816 VARI FLUOR 647 CARBO 5MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000429818 VARI FLUOR 532 CARBO 5MG
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![Medchemexpress LLC Ethanesulfonic acid, 2-[(aminoiminomethyl)amino]- | 543-18-0 | 99.9% | 167.19 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000436072-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Ethanesulfonic acid, 2-[(aminoiminomethyl)amino]- | 543-18-0 | 99.9% | 167.19 | 100 MG
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Guanidinoethyl sulfonate (Standard) is an analytical standard and an orally available, blood-brain permeable competitive inhibitor of taurine transporters. It acts as a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM) and shows weak agonist/antagonist effects on GABAA receptors. It inhibits taurine transmembrane transport, blocks glycine-mediated chloride influx, and may regulate brain pH for neuroprotective effects, useful in studies of ischemic brain injury. It is applied in qualitative, quantitative, and methodological research experiments including HPLC, GC, and MS.
- Analytical standard for research
- Orally available and blood-brain permeable
- Inhibits taurine transporters
- Antagonizes glycine receptors
- Modulates GABAA receptors
- Blocks glycine-mediated chloride influx
- May offer neuroprotective effects
- Used in HPLC, GC, and MS applications
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Medchemexpress LLC Glucagon-like peptide-1 (GLP-1)(7-36), amide | 107444-51-9 | 99.9% | 3297.68 | 1 MG
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Glucagon-like peptide-1 (GLP-1)(7-36), amide is a physiological incretin hormone that stimulates insulin secretion. This peptide has a molecular weight of 3297.68 and appears as a white to off-white solid.
- Stimulates insulin secretion.
- Potent insulin-releasing peptide.
- Product of tissue-specific post-translational processing.
- Released postprandially from intestinal endocrine L cells.
- Normalizes fasting plasma glucose concentrations in Type 2 diabetic subjects (exogenous).
- Soluble in H2O at 100 mg/mL (30.32 mM; requires ultrasonic).
- For research use only.
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Medchemexpress LLC Sulfo DBCO-amine | 2028284-70-8 | 99.0% | 100 MG
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Sulfo DBCO-amine is an alkyl chain-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that possess Azide groups. PROTACs themselves are composed of two distinct ligands connected by a linker, with one ligand targeting an E3 ubiquitin ligase and the other targeting a specific protein, enabling the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group for SPAAC with Azide groups
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Medchemexpress LLC PARP1-IN-31 | 5MG
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PARP1-IN-31 | 5MG
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Chem-Impex International, Inc. 8-Hydroxyquinoline | 148-24-3 | MFCD00006807 | 250G
8-Hydroxyquinoline, 148-24-3, MFCD00006807, 250G
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